报告人：Paul E. Floreancig教授，美国匹兹堡大学
报告题目：Natural Product Synthesis as an Inspiration for Method Development and Biological Studies
报告时间：5月16日（周 四）下午4:10
报告地点：ylzzcom永利总站线路检测211
主办单位：ylzzcom永利总站线路检测、科研院
Paul E. Floreancig，美国匹兹堡大学教授。1986年于印第安纳大学获得学士学位，1989年于耶鲁大学获得硕士学位，1997年于斯坦福大学获得博士学位，1997-1999年于加州理工学院从事博士后研究。1999-2010年于匹兹堡大学先后担任助理教授、副教授，2010年担任匹兹堡大学教授。主要研究兴趣为天然产物全合成、药物化学、合成方法学。
近年代表性论文：
1) Caplan, S. M.; Floreancig, P. E. Total Synthesis of Divergolides E and H Angew. Chem., Int. Ed. 2018, 57, 15866-15870. DOI: 10.1002/anie.201810336.
2) Qin, Q.; Xie, Y.; Floreancig, P. E. Diarylmethane Synthesis through Re2O7-Catalyzed Bimolecular Dehydrative Friedel–Crafts Reactions Chem. Sci. 2018, 9, 8528-8534. DOI: 10.1039/C8SC03570A.
3) Morales-Rivera, C. A.; Floreancig, P. E.; Liu, P. Predictive Model for Oxidative C–H Functionalization Reactivity with 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone J. Am. Chem. Soc. 2017, 139, 17935-17944. DOI: 10.1021/jacs.7b08902.
4) Rohrs, T. M.; Qin, Q.; Floreancig, P. E. Re2O7-Mediated Dehydrative Cyclization Reactions: Application to the Total Synthesis of Herboxidiene and an Analog Angew. Chem., Int. Ed. 2017, 56, 10900-10904. DOI: 10.1002/anie.201705924.
5) Hanna, R. D.; Naro, Y.; Deiters, A.; Floreancig, P. E. Alcohol, Aldehyde, and Ketone Liberation and Intracellular Cargo Release through Peroxide-Mediated Boryl Ether Fragmentation J. Am. Chem. Soc. 2016, 138, 13353-13360. DOI: 10.1021/jacs.6b07890.
6) Han, X.; Floreancig, P. E. Spiroacetal Formation through Telescoped Cycloaddition and Carbon–Hydrogen Bond Functionalization: Total Synthesis of Bistramide A Angew. Chem., Int. Ed. 2014, 53, 11075-11078. DOI: 10.1002/anie.201406819.
7) Xie, Y.; Floreancig, P. E. Allylic Alcohol Transposition-Based Heterocycle Synthesis Using Traceless Trapping Groups Angew. Chem., Int. Ed. 2014, 53, 4926-4929. DOI: 10.1002/anie201402010.
8) Xie, Y.; Floreancig, P. E. Cascade Approach to Stereoselective Polycyclic Ether Formation: Epoxides as Trapping Agents in the Transposition of Allylic Alcohols Angew. Chem., Int. Ed. 2013, 52, 625-628. DOI: 10.1002/anie.201208132.
