姓    名：赵立明

学位学历：博士研究生

职    称：教授

职    务：教研室主任

学科专业：药物化学

Email: lmzhao@jsnu.edu.cn

【个人简历】

2008年7月至今，江苏师范大学化院制药教研室

2021年9月-2022年8月，韩国Seoul National University药学院

2013年10月-2014年10月，美国Purdue University药学院

2008年6月博士毕业于上海交通大学药学院药物化学专业

1998年6月本科毕业于延边大学药学院药学专业；同年7月留校任教，任职于药物化学教研室

【代表性论文】

1. Wang, Y.-J.; Zhao, L.-M.* Synthesis of 10-Membered Azecines through Pd-Catalyzed Formal [6+4] Cycloaddition and Their Transannular Reaction to Polycyclic Compounds. Chemistry - A European Journal 2023, 29, e202302111.

2. Wang, T.-T.; Zhao, L.-M.* Synthesis of 2-arylethenesulfonyl fluorides and isoindolinones: Ru-catalyzed C–H activation of nitrones with ethenesulfonyl fluoride. Chemical Communications 2022, 58, 11099-11102.

3. Li, R.-L.; Fang, Q.-Y.; Li, M.-Y.; Wang, X.-S.; Zhao, L.-M.* A rearrangement of saccharin-derived cyclic ketimines with 3-chlorooxindoles leading to spiro-1,3-benzothiazine oxindoles. Chemical Communications 2021, 57, 11322-11325.

4. Wang, Y.-J.; Wang, T.-T.; Liang, C.-C.; Li, Z.-H.; Zhao, L.-M.* Synthesis of Indolo[2,1‑a]benzazepinones through Rhodium-Catalyzed Cascade Reactions of 2‑Arylindoles with Allyl Alcohols. Organic Letters 2021, 23, 6272-6277.

5. Fang, Q.-Y.; Zhao, L.-M.* A [4+3] annulation of benzofuran-derived azadienes and α-bromohydroxamates for the synthesis of benzofuran-fused 1,4-diazepinones. Chemical Communications 2020, 56, 14079-14082.

6. Fang, Q.-Y.; Yi, M.-H.; Wu, X.-X.; Zhao, L.-M.* Regio- and Diastereoselective Spirocyclopropanation of Benzofuran-Derived Azadienes through 1,4-Addition-Induced Dearomatization Reaction under Mild Conditions. Organic Letters 2020, 22, 5266-5270.

7. Fang, Q.-Y.; Jin, H.-S.; Wang, R.-B.*; Zhao, L.-M.* DABCO-mediated [3+3] cycloaddition of azomethine imines with in situ generated nitrile oxides from hydroximoyl chlorides. Chemical Communications 2019, 55, 10587-10590.

8. Zhang, J.-H.; Mottamal M.; Jin, H.-S.; Guo, S.; Gu, Y.; Wang, G.*; Zhao, L.-M.* Design, Synthesis, and Evaluation of Belinostat Analogs as Histone Deacetylase Inhibitors. Future Medicinal Chemistry 2019, 11, 2765-2778.

9. Zhao, L.-M.*; Zhang, J.-H. Histone Deacetylase Inhibitors in Tumor Immunotherapy. Current Medicinal Chemistry 2019, 26, 2990-3008.

10. Li, D.-F.; Liu, K.; Jiang, Y.-X.; Gu, Y.; Zhang, J.-R.; Zhao, L.-M.* Access to 3-Prenylated Oxindoles by α-Regioselective Prenylation: Application to the Synthesis of (±)-Debromoflustramine E. Organic Letters 2018, 20, 1122-1125.

11. Zhao, L.-M.*; Zhang, A.-L.; Zhang, J.-H.; Gao, H.-S.; Zhou, W. Zinc-Mediated C-3 α-Prenylation of Isatins with Prenyl Bromide: Access to 3-Prenyl-3-hydroxy-2-oxindoles and Its Application. Journal of Organic Chemistry 2016, 81, 5487-5494.

12. Zhao, L.-M.; Jin, H.-S.; Liu, J.; Skaar, T. C.; Ipe, J.; Lv, W.; Flockhart, D. A.; Cushman, M.* A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β. Bioorganic & Medicinal Chemistry 2016, 24, 5400-5409.

13. Zhao, L.-M.*; Cao, F.-X.; Zhang, J.-H.; Szwayab, J.; Wang, G.* One-pot synthesis of 1,4-dihydroxy-2-((E)-1-hydroxy-4-phenylbut-3-enyl)anthracene-9,10-diones as novel shikonin analogs and evaluation of their antiproliferative activities. Bioorganic & Medicinal Chemistry Letters 2016, 26, 2691-2694.

14. Zhao, L.-M.*;Zhang, A.-L.; Gao, H.-S.; Zhang, J.-H. Synthesis of Furo[3,2-c]benzopyrans via an Intramolecular [4 + 2] Cycloaddition Reaction of o-Quinonemethides. Journal of Organic Chemistry 2015, 80, 10353-10358.

15.Zhao, L.-M.*; Ma, F.-Y.; Jin, H.-S.; Zheng, S.; Zhong, Q.; Wang, G.* Design and synthesis of novel hydroxyanthraquinone nitrogen mustard derivatives as potential anticancer agents via a bioisostere approach. European Journal of Medicinal Chemistry 2015, 102, 303-309.

16. Zhao, L.-M.*; Zhang, S.-Q.; Dou, F.; Sun, R. Zinc-Mediated Highly α-Regioselective 1,4-Addition of Chalcones with Prenyl Bromide in THF. Organic Letters 2013, 15, 5154-5157.

17.Zhao, L.-M.*; Zhang, S.-Q.; Jin, H.-S.; Wan, L.-J.; Dou, F. Zinc-Mediated Highly α-Regioselective Prenylation of Imines with Prenyl Bromide. Organic Letters 2012, 14, 886-889.

18. Zhao, L.-M.*; Zhang, L.-M.; Liu, J.-J.; Wan, L.-J.; Chen, Y.-Q.; Zhang, S.-Q.; Yan, Z.-W.; Jiang J.-H. Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin. European Journal of Medicinal Chemistry2012, 47, 255-260.

19. Zhao, L.-M.*; Jin, H.-S.; Wan, L.-J.; Zhang, L.-M. General and Highly α-Regioselective Zinc-Mediated Prenylation of Aldehydes and Ketones. Journal of Organic Chemistry 2011, 76, 1831-1837.

【发明专利】

1. 赵立明，蒋继宏，金海善，刘金娟，张黎明。抗肿瘤活性的大黄素和5-氟尿嘧啶拼合物及其制备方法；201306；ZL201110141407.2

2. 赵立明，马凤燕。具有抗肿瘤活性的羟基蒽醌氮芥衍生物及其制备方法；201511；CN 105037181

3. Cushman, M.; Lv, W.; Zhao, L.-M. Preparation of triphenylethylene compounds and uses thereof in cancer treatment. 201705, US 20170144975

4. 赵立明，张皆欢，金海善。具有组蛋白去乙酰化酶抑制活性的贝利司他的结构类似物及其应用；201802；CN 107698464

5. 赵立明，刘坤。一种氮杂β-取代Morita-Baylis-Hillman型化合物及其合成方法；202106；ZL201910436982.1

6. 赵立明，刘坤。一种氧代吲哚螺吡啶类化合物及其合成方法；202106；ZL201910436943.1

【会议报告】

1. 口头报告，2022 Spring International Convention of The Pharmaceutical Society of Korea, Chungcheongbuk-do C&V Center, Republic of Korea, 2022. 04

2. 口头报告，中国化学会第31届学术年会，杭州，2018. 05

3. 口头报告，第十三届中美华人化学教授会议，南通，2017. 06

4. 口头报告，第九届江淮有机化学论坛，常州，2011. 10